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Scientific studies have shown, however, that the vasodilation effects of Viagra also can improve blood flow to the lungs. This can have a positive effect on conditions in which the blood pressure is elevated in the arteries that supply the lungs, also known as pulmonary arterial hypertension. Most studies assessed the efficacy of sildenafil approximately 60 minutes post-dose 11,12,13,14,15,16,8,9. The erectile response, as assessed by RigiScan®, generally increased with increasing sildenafil dose and plasma concentration 11,12,13,14,15,16,8,9. The risks may include an increased chance of heart attack or stroke among men already at risk of such events—including those with coronary disease—as well as fertility problems and worsened sleep apnea. Sildenafil’s popularity with young adults has increased over the years. This study also noted a significant placebo effect in the control group.

  • Unfortunately, we don’t know much about PDE11, which is found in the heart, in the pituitary gland in the brain and in the testicles.
  • In a recent study on men with erectile dysfunction and diabetes, vardenafil improved their erectile dysfunction.
  • Pharmacokinetics, half-life, is how long the medication stay s in the blood.
  • Sildenafil has a half-life of 4 hours and vardenafil has a half-life of 4-6 hours while tadalafil has a half-life of 17.5 hours.

Studies have produced relevant data on the effects of VIAGRA on cardiac output. In one small, open-label, uncontrolled, pilot study, eight patients with stable ischemic heart disease underwent Swan-Ganz catheterization. Single oral doses of sildenafil administered to healthy volunteers produced decreases in sitting blood pressure (mean maximum decrease in systolic/diastolic blood pressure of 8.3/5.3 mmHg). The decrease in sitting blood pressure was most notable approximately 1-2 hours after dosing, and was not different than placebo at 8 hours.

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Other drugs may interact with sildenafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Keep your diabetes under control, and you can lower your risk of sexual and urologic problems. Senior Sex Enjoying a satisfying sex life as we age is important to both physical and mental health. As we age, diseases and conditions may pose challenges in our sexual health, and sexual experiences. Learn how to manage your conditions and still have a gratifying sex life as you age. Men may take it socially with other drugs, rather than for treatment of a medical condition. Night Sweats Night sweats are severe hot flashes that occur at night and result in a drenching sweat.

Viagra (sildenafil (injection))

This increases blood flow and allows you to get an erection in response to sexual stimulation. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex , Cerner Multum™ , ASHP and others.

what are viagra pills

For patients with the most severe forms of erectile dysfunction, often resulting from nerve damage due to diabetes or prostate cancer surgery, Viagra typically doesn’t work at all. Men also should not take Viagra if they are also taking any other medication for high blood pressure, such as Revatio or other drugs. However, in an early trial, the drug did not produce the heart effects the researchers had hoped for. But a number of study volunteers reported an interesting side effect — they had stronger and more persistent erections. Other studies conducted around the same time revealed that sildenafil’s molecular target may play a role in erections. That spurred a new study of the drug for men with erectile dysfunction, which found that sildenafil was effective in 82 percent of men who received the highest study dose, according to the review. The medication was originally developed and studied as an anti-hypertensive drug to treat high blood pressure as well as a type of cardiovascular disease called angina pectoris.

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You’ll need to talk to your healthcare provider if you’re considering either, as they have the same drug interactions, including nitrates . Sildenafil is in a class of medications called phosphodiesterase inhibitors. Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual stimulation. Sildenafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow easily. But the side effects of sildenafil citrate, even with a prescription, can be intense. To start with, there are often prominent side-effects ranging from headaches to stomach pain.

Mean resting values for right atrial pressure, pulmonary artery pressure, pulmonary artery occluded pressure and cardiac output decreased by 28%, 28%, 20% and 7% respectively. This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor’s approval. Before considering how Viagra might be linked to sports, it is important to understand how the drug works. Simply put, Viagra is a vasodilator, meaning it helps relax blood vessels to allow for increased blood flow. In the presence of sexual stimulation, this increased blood flow is the means of counterattack against erectile dysfunction.

Pulmonary Hypertension